Gentile Virginio Orsini (c. 1434 – 8 January 1497) was an Italian condottiero and vassal of the papal throne and the Kingdom of Naples, mainly remembered as the powerful head of the Orsini family during its feud with Pope Alexander VI (Rodrigo Borgia). Though best known as Lord of Bracciano, during his lifetime he bore many titles, among which Count of Tagliacozzo, Vicovaro and Anguillara, Lord of Cerveteri, Knight of the Order of Emellino (1463), Constable of the Kingdom of Naples and Gonfalonier of the Roman Church. The aforesaid fiefs were all confiscated in favor of the Colonna family or the Borgia family during Virginio's conflict with Naples and the Pope.
Almighty due to pontifical benefices, Virginio took advantage of the disorder which followed Sixtus's death (1484) in order to exterminate the Roman house of Colonna family, something he didn't manage completely due to the Sacred College’s restoring the order. During the reign of Innocent VIII (1484–1492), the Orsini family reached the peak of its power and held significant influence over the Roman Curia through Virginio's cousin, Cardinal Giambattista Orsini of Monterotondo. The ascension of Alexander VI to the papal throne (August 1492) changed the status quo in the Roman politics.
When Charles VIII of France seized Rome in the December 1494, demanding from the Pope to crown him monarch of Naples, the Orsini family hosted his troops in its fortresses and clamored for Alexander VI's deposition together with the Colonna family and most of the Cardinals. Thus Virginio, who had also been named Constable of Naples, betrayed both the Pope and the Aragonese dynasty of Naples. Hoping to gain benefits for his house by the French king, Virginio followed the French on their campaign in Naples. After the defeat of the French in the Battle of Fornovo (6 June 1495) and the restoration of the Aragonese in Naples the same month, Virginio was arrested and imprisoned by Ferdinand II of Naples, the new Neapolitan king, with the consent of the Pope. He died probably of poison in the Castel dell'Ovo, in Naples (8 January 1497), while Alexander VI was confiscating the Orsini strongholds in the Papal States in favor of the Borgia.
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